Multiple Non-Melanoma Skin Cancer: Evidence that Different MHC Genes are Associated with Different Cancers
作者:
D. Czarnecki,
B. Tait,
I. Nicholson,
A. Lewis,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 188,
issue 2
页码: 88-90
ISSN:1018-8665
年代: 1994
DOI:10.1159/000247107
出版商: S. Karger AG
关键词: Multiple non-melanoma skin cancer;HLA;DR1;DR4;DR7;DR53
数据来源: Karger
摘要:
HLA DR frequencies of patients with multiple non-melanoma skin cancers were analysed. There were significant differences in the frequencies of HLA DR1 DR4 and DR7 between patients who only had basal cell carcinomas and patients who had both basal and squamous cell carcinomas. There were significant differences in the frequency of HLA DR53 between the two groups. This antigen is in linkage disequilibrium with HLA DR4 and DR7, and it is not possible to distinguish the primary susceptibility locus.
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