Prostaglandin E and F Profiles in Human Fallopian Tubes during Different Phases of the Menstrual Cycle
作者:
J. Nieder,
W. Augustin,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1986)
卷期:
Volume 21,
issue 4
页码: 202-207
ISSN:0378-7346
年代: 1986
DOI:10.1159/000298955
出版商: S. Karger AG
关键词: Prostaglandins;Fallopian tube;Menstrual cycle
数据来源: Karger
摘要:
Prostaglandin (PG)E and F equivalents have been determined in fallopian tubes from 26 women by radioimmunoassays following appropriate extraction and separation procedures. Both PGE and F equivalents at ranges between 5 and 100 ng/g wet weight exhibit profiles of increasing concentrations along the oviduct with low contents at the uterotubal junction and maximal levels in the fimbrial region. During the luteal phase of the cycle about 2-fold higher levels of PGE and F equivalents were detected than during the follicular phase in both the ampullary and isthmic portion of the oviduct. A general decline of PG levels was observed in tissues from patients at the perimenopause. The distribution of PGs within the oviduct is compatible with a preferential localization in its mucosal part, which may represent the main target for a progesterone-mediated stimulation of PG production during the luteal phase.
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