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Lack of sex-related differences in the prevention by baclofen of the morphine withdrawal syndrome in mice

 

作者: S.L. Diaz,   A.K. Kemmling,   M.C. Rubio,   G.N. Balerio,  

 

期刊: Behavioural Pharmacology  (OVID Available online 2001)
卷期: Volume 12, issue 1  

页码: 75-79

 

ISSN:0955-8810

 

年代: 2001

 

出版商: OVID

 

关键词: behavioral sex-related differences;morphine withdrawal syndrome;prevention by baclofen;mouse

 

数据来源: OVID

 

摘要:

In previous studies we have demonstrated a possible interaction between the GABAergic and opioid systems involved in the antinociceptive effect of the GABABagonist, baclofen (BAC). On the other hand, sex differences have been observed for the antinociceptive effect of morphine (MOR). In the present study, we analyzed sex-related differences in the MOR abstinence syndrome and its prevention with BAC. Prepubertal male and female Swiss–Webster albino mice (27–33 g) were rendered dependent by intraperitoneal (i.p.) injection of MOR (2, 4 and 8 mg/kg), twice daily for 9 days. On the tenth day the dependent animals were divided into two groups: one received naloxone (NAL) (6 mg/kg, i.p.) 60 min after the last dose of MOR, to precipitate the abstinence syndrome; the other group received BAC (2 mg/kg, i.p.) followed by NAL (6 mg/kg, i.p.), injected 30 and 60 min after the last dose of MOR, respectively. Behavioral signs were recorded in the open field for 30 min. Although there were sex differences in the MOR withdrawal syndrome, we found a lack of sex differences in the prevention of the MOR abstinence syndrome by BAC.

 

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