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Prediction of transient temperature fields and cumulative tissue destruction for radio frequency heating of a tumor

 

作者: Linda J. Hayes,   Kenneth R. Diller,   John A. Pearce,   Mark R. Schick,   David P. Colvin,  

 

期刊: Medical Physics  (WILEY Available online 1998)
卷期: Volume 12, issue 6  

页码: 684-692

 

ISSN:0094-2405

 

年代: 1998

 

DOI:10.1118/1.595649

 

出版商: American Association of Physicists in Medicine

 

数据来源: WILEY

 

摘要:

A therapeutic hyperthermia protocol using a radio frequency (rf) electrode placed adjacent to a bronchial wall tumor has been modeled using the finite element technique. Variable physical properties and variable blood perfusion have been assigned to the tumor and to the surrounding normal lung tissue. The Laplace equation was solved on a curvilinear grid for a single rf source electrode to determine the steady‐state electric field, which in turn governs the energy deposition function. The heat generation in the tumor and in the lung tissue is then calculated from the energy deposition profile, and the bioheat equation is solved on the same finite element mesh to determine the transient temperature history. The temperatures are displayed as isothermal contours at designated times during the protocol and as temperature histories at selected points. In addition, an Arrhenius‐type injury model has been implemented to predict thermally induced damage, from which injury contours and injury histories are produced. Several protocols are investigated in which equal total amounts of energy are deposited into the tissue using a constant power density for an appropriate time or using a cyclic heating pattern. The cyclic heating pattern consisted of a series of equal duration time periods during which the rf current source is alternately turned on and off (50% duty cycle). This study illustrates how a finite element model could be used to evaluate alternative protocols for heating a tumor of a specific geometry and to evaluate thermally induced damage to surrounding normal tissue.

 

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