Effects of Anti-Motion Sickness Drugs on Motion Sickness in Rats
作者:
Masahiro Morita,
Noriaki Takeda,
Takeshi Kubo,
Atsushi Yamatodani,
Hiroshi Wada,
Toru Matsunaga,
期刊:
ORL
(Karger Available online 1988)
卷期:
Volume 50,
issue 5
页码: 330-333
ISSN:0301-1569
年代: 1988
DOI:10.1159/000276008
出版商: S. Karger AG
关键词: Motion sickness;Animal model;Rats;Anti-motion sickness drugs;Pica
数据来源: Karger
摘要:
Pica, the eating of nonnutritive substances such as kaolin, can be induced by rotation in rats. We used this rotation-induced pica as a behavioral index of motion sickness in rats and examined whether diphenhydramine, methamphetamine and scopolamine, which are anti-motion sickness drugs for humans, are effective for reducing motion sickness in rats. Intraperitoneal injection of diphenhydramine or methamphetamine suppressed the rotation-induced kaolin intake of rats. Intraperitoneal injection of scopolamine had no effect on the rotation-induced kaolin intake, but its transdermal administration reduced this kaolin intake. These findings show that human antimotion sickness drugs also prevent motion sickness in rats. Since the pharmacological mechanisms for preventing motion sickness in rats and humans are similar, we conclude that rats are a suitable animal model for use in studies on putative anti-motion sickness drugs.
点击下载:
PDF
(1432KB)
返 回