Developmental Origins, Specificities and Immunoglobulin Gene Biases of Murine Ly-1 B Cells
作者:
HardyRichard R.,
HayakawaKyoko,
期刊:
International Reviews of Immunology
(Taylor Available online 1992)
卷期:
Volume 8,
issue 2-3
页码: 189-207
ISSN:0883-0185
年代: 1992
DOI:10.3109/08830189209055573
出版商: Taylor&Francis
关键词: Ly-1 B;CD5+B cells;B cell development;anti-BrMRBC;anti-thymocyte autoantibody;immunoglobulin repertoire
数据来源: Taylor
摘要:
Ly-1 B cells in mouse show numerous phenotypic and functional features that distinguish them from the bulk of IgDhigh/Ly-1−B cells. Their association with autoantibody production and the presence of Ly-1 on a group of murine B lymphomas that also exhibit certain specificities enriched in the normal population has stimulated continuing interest in this population. We have taken two approaches in our investigations of these cells: 1) defining the origins of Ly-1 B cells (the“lineage question”); and 2) studying the expression of particular specificities and associated immunoglobulin V genes enriched in this population. In this review we present the experimental background that supports our current understanding of Ly-1 B cells as the remnant of a fetal B cell differentiation pathway and suggest that the selection of cells from this fetal/neonatal population into the adult long-lived pool results in the over-expression of certain germline-encoded autoreactivities, such as antibody to bromelain-treated mouse red blood cells and intact thymocytes.
点击下载:
PDF (1026KB)
返 回