Development of Antiviral Levels of Ribavirin in Serum and Urine of Orally Treated Rats
作者:
Donald F. Smee,
Robert W. Sidwell,
Bill B. Barnett,
Rex S. Spendlove,
Raghubir P. Sharma,
期刊:
Chemotherapy
(Karger Available online 1981)
卷期:
Volume 27,
issue 1
页码: 12-17
ISSN:0009-3157
年代: 1981
DOI:10.1159/000237949
出版商: S. Karger AG
关键词: Ribavirin;1-%beta;-D-Ribofuranosyl-1;2;4-triazole-3-carboxamide;Bioassay;Rat serum and urine;Antiviral;Measles virus
数据来源: Karger
摘要:
The levels of ribavirin or its antivirally active metabolic products were determined in the serum and urine of rats treated with single oral doses of 1,000 or 100 mg/kg of the compound, using a newly developed micromethod in which measles virus inhibition was assayed in BS-C-1 cells. At the high dosage level, maximum ribavirin serum levels of 24 μg/ml were observed 2 h postribavirin administration. Approximately 10-fold less active material was seen in the rats receiving the lower ribavirin dosage; this peak effect was seen 1 h after treatment. Urine excretion was maximal between 4 and 20 h after treatment in both dosage groups
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