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Synthesis of indeno[1,2,3-ij]isoquinolines

 

作者: Hemant A. Patel,   David B. MacLean,  

 

期刊: Canadian Journal of Chemistry  (NRC Available online 1983)
卷期: Volume 61, issue 1  

页码: 7-13

 

ISSN:0008-4042

 

年代: 1983

 

DOI:10.1139/v83-002

 

出版商: NRC Research Press

 

数据来源: NRC

 

摘要:

1-Methyl and 1-benzyl-1,2,3,10b-tetrahydro-5,6,8,9-tetramethoxyindeno[1,2,3-ij]isoquinoline have been synthesized from the corresponding 8-phenyl-3,4-dihydro-1(2H)isoquinolinones by treatment with POCl3under Vilsmeier conditions followed by borohydride reduction. The isoquinolinones were prepared in six steps from 2-(2,3,4-trimethoxyphenyl)-4,4-dimethyl-2-oxazoline. This sequence of reactions provides a new route to dihydro and tetrahydroindeno[1,2,3-ij]isoquinoline

 

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