Stress Affects the Activated Form of the Corticosteroid‐Receptor Complex in the Rat Brain
作者:
Ioanna G. Maroulakou,
Efthimia Kitraki,
Fotini Stylianopoulou,
期刊:
Journal of Neuroendocrinology
(WILEY Available online 1992)
卷期:
Volume 4,
issue 1
页码: 15-19
ISSN:0953-8194
年代: 1992
DOI:10.1111/j.1365-2826.1992.tb00339.x
出版商: Blackwell Publishing Ltd
关键词: stress;brain;corticosteroid receptors;proteolysis;chromatography
数据来源: WILEY
摘要:
AbstractGlucocorticoid actions in the brain, particularly in the hippocampus and the hypothalamus, are critically involved in the response of the organism to stress. The key molecules in this process are the corticosteroid receptors, which upon activation, migrate and act in the nucleus. We have investigated the effect of stress on the activated form of the cytosolic glucocorticoid receptor from the above brain areas, using anion exchange chromatography. Exposure of rats to chronic stress resulted in the disappearance of the chromatographic peak, which corresponds to the activated form (DE II) of the hormone‐receptor complex. For this phenomenon to occur, 1) the animal must be exposed to chronic, and not to acute stress, and 2) the adrenals of the animal must be intact. The disappearance of the activated form of the hormone‐receptor complex (DE II) following chronic stress is most probably due to proteolysis of the receptor molecule, since it is specifically inhibited by the protease inhibitor leupeptin. This phenomenon may represent an adaptive mechanism which helps the organism cope with a repeated stres
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