Effect of Antibiotics on the Phagocytosis and Killing ofPseudomonas aeruginosaby Rabbit Polymorphonuclear Leukocytes
作者:
Minoru Nishida,
Yasuhiro Mine,
Shigeo Nonoyama,
Yoshiko Yokota,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 3-4
页码: 203-210
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221927
出版商: S. Karger AG
关键词: P. aeruginosa;PMN;Phagocytosis and killing activity;Carbenicillin;Sulbenicillin;Gentamicin;DKB;Colistin;Polymyxin B
数据来源: Karger
摘要:
The effect of antibiotics on phagocytosis and killing of Pseudomonas aeruginosa by rabbit polymorphonuclear leukocytes was studied. Carbenicillin and sulbenicillin, when added to an incubation medium at a concentration as low as 1/16 MIC, increased phagocytosis and killing of P. aeruginosa by PMN. Meanwhile, gentamicin and 3’,4’-dideoxykanamycin B gave no influence on the PMN activity, and polymyxin B and colistin enhanced the activity only at MIC. The PMN activity was not facilitated even when the cells of P. aeruginosa had been pretreated with antibiotics. The bactericidal activity of PMN decreased after sonification, but was restored following addition of carbenicil
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