Fluid catalytic cracking (FCC) is one of the most complex processes in the petroleum industry. The large degree of uncertainty in the kinetics of the cracking reactions and catalyst deactivation by coke deposition in the riser reactor are among several factors that contribute to the process complexity. The model developed by the authors (Ali and Rohani, 1995) is used lo investigate the effect of the three-lumped kinetic scheme (Weekman and Nace, 1970) and the four-lumped scheme (Lee ct ah, 1989) on the model predictability and reliability. The effect of changes in the catalyst circulation rate, gas oil feed rate, and oxygen feed concentration on various process variables is compared. It is shown that the three-lumped kinetic scheme, despite its extensive use in the literature (McFarlane et ah, 1993; Elnashaie and Elshishini, 1993; Theologos and Markatos, 1993; Arandes and de Lasa, 1992; Lopez-lsunza and Ruiz-Martinez, 1991), leads to erroneous results and should not be used in the dynamic simulation of the FCC units,