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Effect of Tiacrilast, a Mast Cell Mediator-Release Inhibitor, on Murine Experimental Contact Dermatitis

 

作者: M. Csatò,   Rita Judák,   B. Bozóky,   B.M. Czarnetzki,  

 

期刊: Skin Pharmacology and Physiology  （Karger Available online 1990）
卷期: Volume 3, issue 3  

页码: 164-170

 

ISSN:1660-5527

 

年代: 1990

 

DOI:10.1159/000210866

 

出版商: S. Karger AG

 

关键词: Mast cells;Contact dermatitis;Tiacrilast;Mast cell release

 

数据来源: Karger

 

摘要:

The effect of tiacrilast, a mast cell mediator-release inhibitor, was studied in dinitrofluorobenzene-induced allergic and croton oil- or dimethyl sulfoxide-induced irritant murine contact dermatitis. At 1 % concentration, the compound significantly reduced the ear swelling in both allergic and irritant dermatitis and preserved the mast cell architecture on histopathology. These findings suggest that mast cells participate in the elicitation of murine contact dermatitis.

 

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