The Hox-2.4 Gene is not Involved in the Generation of IL-3 Dependent Multipotent FDCP-Mix Cell Lines
作者:
JustUrsula,
KanOn,
FennellyJan,
DexterT. Michael,
SpooncerElaine,
期刊:
Growth Factors
(Taylor Available online 1995)
卷期:
Volume 12,
issue 3
页码: 173-177
ISSN:0897-7194
年代: 1995
DOI:10.3109/08977199509036877
出版商: Taylor&Francis
关键词: Hox2.4;FDCP-mix
数据来源: Taylor
摘要:
AbstractThe establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently derived multipotent IL-3-dependent cell lines established from either src-virus-infected long-term bone marrow cultures (FDCP-mix) or Multi-CSF-virus (M3MuV)-infected bone marrow revealed that Hox-2.4 was not expressed in any of these cell lines. In addition DNA rearrangements were not observed. We conclude that activation of Hox-2.4 is not an obligatory event in the immortalization of early myeloid cells.
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