Serum Bile Acids, Gamma-Glutamyltransferase and Routine Liver Function Tests in Emetic and Nonemetic Pregnancies
作者:
A. Järnfelt-Samsioe,
B. Eriksson,
J. Waldenström,
G. Samsioe,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1986)
卷期:
Volume 21,
issue 4
页码: 169-176
ISSN:0378-7346
年代: 1986
DOI:10.1159/000298949
出版商: S. Karger AG
关键词: Human pregnancy;Emesis gravidarum;Serum bile acids;γ-Glutamyltransferase;Routine liver function tests
数据来源: Karger
摘要:
The etiology of nausea and vomiting in pregnancy is still unknown. One possibility is that ovarian and placental hormones may play some part. The liver is the major site of metabolic inactivation of steroid hormones. In this study, 102 healthy pregnant women, of whom 62 complained of nausea, were followed throughout pregnancy. Liver function tests were performed to ascertain whether emesis gravidarum is related to impaired hepatic function. In this series, all values were within the normal ranges. Serum levels of total bilirubin and gamma-glutamyl-transferase were significantly decreased and those of total serum bile acids significantly increased in emetic women compared to nonemetic subjects. Furthermore, the metabolic load on the liver seems to follow a biphasic course as there is an apparent minimum in liver function variables in the second trimester. It is concluded that a slow adaptation to the increased hormonal load on the liver might be responsible for the condition of emesis gravidarum.
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