Carbon-14-Urea Breath Test as a Noninvasive Method to MonitorHelicobacterfelisColonization in Mice
作者:
Micheline Glauser,
Pierre Michetti,
André L. Blum,
Irene Corthésy-Theulaz,
期刊:
Digestion
(Karger Available online 1996)
卷期:
Volume 57,
issue 1
页码: 30-34
ISSN:0012-2823
年代: 1996
DOI:10.1159/000201309
出版商: S. Karger AG
关键词: Helicobacter felisinfection;14C-urea breath test in mice;method
数据来源: Karger
摘要:
We have developed a 14C-urea breath test to follow the course of Helicobacter felis infection in mice. Peak 14CO2 production occurred approximately 8 min after substrate administration. The test values were compared to those from a rapid urease test and correlated with the presence of pathogens by histology. The sensitivity was 99%, specificity 91%, positive predictive value 95% and negative predictive value 99% when the assay was conducted in fasted mice. We conclude that in mice the breath test analysis is a useful noninvasive method for detecting the presence of H. felis or for evaluating therapeutic agents affecting growth or survival of the organism.
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