Cellular Immune Mechanisms in Chronic Autoimmune Thrombocytopenic Purpura (ATP)
作者:
SempleJohn W.,
FreedmanJohn,
期刊:
Autoimmunity
(Taylor Available online 1992)
卷期:
Volume 13,
issue 4
页码: 311-319
ISSN:0891-6934
年代: 1992
DOI:10.3109/08916939209112340
出版商: Taylor&Francis
关键词: Autoimmunity;thrombocytopenia;platelets;immunoregulation;T helper cells;NK cells
数据来源: Taylor
摘要:
Chronic autoimmune thrombocytopenic purpura (ATP) is a common autoimmune-mediated bleeding disease in which autoantibodies are directed against platelets, resulting in their enhanced Fc-mediated destruction by macrophages in the spleen. While there has been extensive studies relating to the autoantibodies in this autoimmune disorder, relatively few have dealt with cell-mediated immunoregulation of the anti-platelet autoanti-body response. Nonetheless, there is accumulating evidence that suggests the production of these anti-platelet autoantibodies is under the influence of several abnormal lymphocyte-mediated mechanisms, i.e. enhanced anti-platelet T helper cell activity with concomitant reduced T suppressor cell activity. This review focuses on these cellular events and presents a working model which attempts to explain their close interrelationships.
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