FK 506 Reduces the Injury Experienced Following Renal Ischemia and Reperfusion
作者:
Van ThielDavid H.,
SakrMahmoud,
ZettiGiorgio,
McClainCraig,
期刊:
Renal Failure
(Taylor Available online 1992)
卷期:
Volume 14,
issue 3
页码: 285-288
ISSN:0886-022X
年代: 1992
DOI:10.3109/08860229209106630
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The effect of FK 506 pretreatment on renal ischemia and reperfusion (I/R) injury was investigated. Adult male rats were assigned to one of two groups (20 animals each). Group 1 (controls) received 0.5 mL saline while group 2 recieved FK 506 (0.3 mg/kg) intravenously 24 h prior to the induction of renal ischemia. After a 60-min period of ischemia of the right kidney, a left nephrectomy was performed. Blood for BUN, creatinine, and tumor necrosis factor (TNF) was obtained prior to ischemia and on days 1, 2, 3, 5, 7, and 10. All surviving animals were sacrificed at day 10. FK 506 pretreatment reduced the serum levels of BUN (p<. 02), creatinine (p<. 02) and TNF (p<. 05) as compared to that seen in controls. Based upon these data, it appears that: (a) renal ischemia induces the release of TNF; (b) FK 506 pretreatment inhibits TNF production; and (c) FK 506 reduces renal injury association with I/R.
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