α‐Adrenoceptor Stimulation With Exogenous Norepinephrine or Release of Endogenous Catecholamines Mimics Ischemic Preconditioning
作者:
Zehyani Bankwala,
Sharon Hale,
Robert Kloner,
期刊:
Circulation
(OVID Available online 1994)
卷期:
Volume 90,
issue 2
页码: 1023-1028
ISSN:0009-7322
年代: 1994
出版商: OVID
关键词: norepinephrine;tyramine;myocardium;α1-adrenergic agonists
数据来源: OVID
摘要:
BackgroundBrief episodes of ischemia induced by proximal coronary artery occlusion can precondition the myocardium. Whether other stressful stimuli have the potential to protect the myocardium from subsequent ischemia remains controversial.Methods and ResultsTo study the hypothesis that transient α-adrenoceptor stimulation mimics preconditioning, for 5 minutes we administered 0.25 μg · kg−1spkg min−1norepinephrine or saline 10 minutes before a 30-minute coronary occlusion and 4 hours of reperfusion in an in vivo rabbit model. The area of necrosis (AN) and area of risk (AR) were measured. We found that norepinephrine pretreatment caused a reduction in infarct size when compared with controls (AN/AR, 0.17±0.04 versus 0.31±0.04;P<.02). Ischemic preconditioning also reduced infarct size (AN/AR, 0.22±0.03). The protection observed with norepinephrine treatment was entirely eliminated by pretreatment with α-adrenergic blockade using prazosin (AN/AR, 0.42±0.06). Tyramine, an agent that causes release of endogenous catecholamines, was administered (1.5 mg/kg IV) 10 minutes before coronary occlusion in another group of rabbits. Tyramine pretreatment resulted in a smaller infarct size than in untreated controls (AN/AR, 0.16±0.04 versus 0.41±0.07;P<.01). Both norepinephrine and tyramine caused an increase in systemic arterial pressure during infusion; tyramine also increased heart rate. In rabbits pretreated with prazosin, heart rate and systemic pressure during the norepinephrine infusion were similar to baseline values. During coronary occlusion, the degree of ischemia was similar in all groups.ConclusionsExposure of the heart to either transient exogenous norepinephrine or endogenous release of norepinephrine and/or other catecholamines by tyramine can mimic the effects of ischemic preconditioning in rabbits.
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