Tautology or not tautology?
作者:
Edmund Crouch,
Richard Wilson,
Lauren Zeise,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1987)
卷期:
Volume 20,
issue 1-2
页码: 1-10
ISSN:0098-4108
年代: 1987
DOI:10.1080/15287398709530957
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
It has been suggested that the good correlations found between carcinogenic potency in mice and in rats could be an artifact. The artifact suggested arises because there are four correlations to consider—interspecies correlations of toxicity, interspecies correlations of carcinogenic potency, and two intraspecies correlations between toxicity and carcinogenic potency—and the existence of any three implies the fourth. It was argued that the intraspecies correlations between toxicity and potency were due to criteria for data selection. Here we discuss the correlations in detail and show that they are principally due to the experimental observation that there are few cases where most or all animals in a bioassay get cancer. We conclude that the correlations between carcinogenic potency are valid.
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