Iron Deficiency in the RatBiochemical Studies of Brain Metabolism
作者:
BRUCE MACKLER,
RICHARD PERSON,
LOUISE MILLER,
A. INAMDAR,
C. FINCH,
期刊:
Pediatric Research
(OVID Available online 1978)
卷期:
Volume 12,
issue 3
页码: 217-220
ISSN:0031-3998
年代: 1978
出版商: OVID
关键词: Aldehyde oxidase;brain metabolism;iron deficiency
数据来源: OVID
摘要:
SummaryStudies were performed to determine the effects of iron deficiency on brain metabolism in rats. Concentrations of cytochrome pigments, oxidative phosphorylation, and catalase and monoamine oxidase activities in brain tissue were unaffected by iron deficiency. However, activities of aldehyde oxidase, a key enzyme in the pathway of serotonin degradation, were significantly reduced, and concentrations of serotonin and total 5-hydroxyindole compounds were elevated in brain tissue of iron-deficient animals. Aldehyde oxidase activities and concentrations of 5-hydroxyindole compounds in brain tissues returned to approximately normal values one week after treatment of iron deficient animals with iron dextran.SpeculationStates of iron deficiency may result in reduction of important iron containing enzymes in brain tissue and altered brain metabolism.
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