Haloperidol Plasma Levels and Acute Clinical Change in Schizophrenia
作者:
WILLIAM,
CORYELL MICHAEL,
KELLY PAUL,
PERRY DEL,
期刊:
Journal of Clinical Psychopharmacology
(OVID Available online 1990)
卷期:
Volume 10,
issue 6
页码: 397-402
ISSN:0271-0749
年代: 1990
出版商: OVID
数据来源: OVID
摘要:
&NA;Twenty‐five inpatients with acute exacerbations of schizophrenia (by Research Diagnostic Criteria) or schizoaffective disorder underwent a prospective haloperidol dosing procedure and were assigned fixed doses chosen to yield a distribution of haloperidol plasma levels above and below a hypothesized upper therapeutic limit of 18 ng/ml. Changes in Brief Psychiatric Rating Scale scores after 1 week of treatment were negatively correlated with haloperidol plasma levels, and the statistically optimum cutoff point fell near the predicted 18 ng/ml. Plasma level/response relationships over the subsequent 3 weeks were weaker but patients with higher plasma levels had consistently less improvement.(J Clin Psychopharmacol 1990;10:397‐402)
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