Schizophrenic psychoses and theCNTFnull mutation
作者:
Yuji Tanaka,
Hiroshi Ujike,
Yutaka Fujiwara,
Toshihiko Takeda,
Yasushi Takehisa,
Masafumi Kodama,
Saburo Otsuki,
Shigetoshi Kuroda,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 6
页码: 981-983
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Ciliary neurotrophic factor;Genetics;Neurotrophic factor;Null mutation;Psychiatry;Schizoaffective disorder;Schizophrenia
数据来源: OVID
摘要:
Genetic susceptibility plays an important role in the development of schizophrenic psychoses, and the neural maldevelopment hypothesis is suggested by neuropathological and neuroimaging findings. We investigated the association between a null mutation in the ciliary neurotrophic factor (CNTF) gene and functional psychoses including schizophrenia and schizoaffective disorder. The frequency of mutant allele was significantly increased in patients with schizoaffective disorder, but not in those with schizophrenia in comparison with controls. TheCNTFnull mutation resulting in CNTF deficiency may confer potential susceptibility to schizoaffective disorder.
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