Assignment of the mouse homologue of a human MEN1 candidate gene, phospholipase C-β3 (Plcb3), to chromosome region 19B by FISH
作者:
A.E. Gobl,
B.P. Chowdhary,
W. Shu,
L. Eriksson,
C. Larsson,
G. Weber,
K. Öberg,
B. Skogseid,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1995)
卷期:
Volume 71,
issue 3
页码: 257-259
ISSN:1424-8581
年代: 1995
DOI:10.1159/000134122
出版商: S. Karger AG
数据来源: Karger
摘要:
A recent study using comparative mapping analysis suggests that the proximal segment of mouse chromosome 19 contains the mouse homologs of the human multiple endocrine neoplasia type 1 (MENl) flanking markers proximal to the locus. We have recently shown that phospholipase C-β3 (PLCB3) is a candidate gene for the MENl syndrome. In the present investigation we used fluorescence in situ hybridization with a genomic DNA clone for mouse Plcb3, and mapped the locus to chromosome region 19B. This is in agreement with the comparative mapping of the MENl flanking markers in mouse
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