Adenosine receptor mediated stimulation of ventilation in man
作者:
B. JONZON,
C. SYLVÉN,
B. BEERMANN,
R. BRANDT,
期刊:
European Journal of Clinical Investigation
(WILEY Available online 1989)
卷期:
Volume 19,
issue 1
页码: 65-71
ISSN:0014-2972
年代: 1989
DOI:10.1111/j.1365-2362.1989.tb00308.x
出版商: Blackwell Publishing Ltd
关键词: Adenosine;theophylline;dipyridamole;respiration;afferent nerves
数据来源: WILEY
摘要:
Abstract.We wanted to examine how adenosine stimulates ventilation in man. Bolus doses of adenosine were given i.v. in an antebrachial vein in multiples of 2.65 mg. The minute ventilation was increased by adenosine 5.3 to 15.9 mg (median values) from control 12.6 ± 1.9 1 min‐1to 42.5 ± 4.7 1 min‐1in a dose‐dependent manner. The adenosine receptor antagonist theophylline, 58.3 ± 3.3 (mean±SEM) µniol 1‐1plasma, inhibited the response by approximately 25%. Dipyridamole 10 mg, an adenosine uptake blocker, enhanced the effect of adenosine by approximately 60%. The ventilation was not affected by metoprolol, atropine, naloxone or cromolyn sodium but was attenuated by hyperventilation.The respiratory stimulation started before chest pain and cardiovascular effects such as AV‐block were encountered. It is concluded that this respiratory stimulation shows characteristics of adenosine receptor mediated responses but the location of such adenosine receptors is uncertain. The findings are compatible with a stimulatory or facilitating effect of adenosine on aff
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