Amitriptyline Dosage Prediction in Elderly Patients from Plasma Concentration at 24 Hours after a Single 100mg Dose
作者:
S. Dawling,
S. Ford,
D. C. Rangedara,
R. R. Lewis,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1984)
卷期:
Volume 9,
issue 3
页码: 261-266
ISSN:0312-5963
年代: 1984
出版商: ADIS
数据来源: ADIS
摘要:
Fifteen depressed elderly patients (14 female, 1 male; mean age 85 years) received a single oral dose of amitriptyline. The concentration of amitriptyline plus nortriptyline in a blood sample taken 24 hours later was used to predict by means of a nomogram the amitriptyline dosage required for each patient. Each dose was selected to produce steadystate amitriptyline plus nortriptyline concentrations close to 140 &mgr;g/L. The daily dosage ranged from 20 to 100mg (mean 62mg).Patients received the individually calculated dose each night, and weekly blood samples were obtained for drug analysis. At 2 weeks, mean amitriptyline plus nortriptyline concentrations were 118 ± 21 &mgr;g/L. Eight of the patients were studied for a further 2 weeks and the mean amitriptyline plus nortriptyline concentration was then 111 + 19 &mgr;g/L.The dose prediction test is easy to use and ensures each patient receives an adequate but safer dose of amitriptyline than might otherwise be prescribed routinely.
点击下载:
PDF
(381KB)
返 回