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Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities

 

作者: Marc Leopold Hautekeete,   Jean Henrion,   Serge Naegels,   André DeNeve,   Michael Adler,   Carlne Deprez,   Ghislain Devis,   Günter Klöppel,  

 

期刊: Liver  （WILEY Available online 1995）
卷期: Volume 15, issue 1  

页码: 25-29

 

ISSN:0106-9543

 

年代: 1995

 

DOI:10.1111/j.1600-0676.1995.tb00102.x

 

出版商: Blackwell Publishing Ltd

 

关键词: benzarone;benzofurans;chronic active hepatitis;fulminant hepatitis;cirrhosis;drug hypersensitivity

 

数据来源: WILEY

 

摘要:

We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative. Our cases include a 35‐year‐old woman with (sub)fulminant hepatitis, a 67‐year‐old woman with macronodular cirrhosis, and a 68‐year‐old man with severe chronic active hepatitis and cirrhosis, with positivity of anti‐smooth muscle antibodies. Two patients died. We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis. Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related

 

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