Assessment of Cerebral Autoregulation with Ultrasound and Laser Doppler Wave Forms‐‐An Experimental Study in Anesthetized Rabbits
作者:
Marek Czosnyka,
Hugh Richards,
Peter Kirkpatrick,
John Pickard,
期刊:
Neurosurgery
(OVID Available online 1994)
卷期:
Volume 35,
issue 2
页码: 287-293
ISSN:0148-396X
年代: 1994
出版商: OVID
关键词: Arterial hypotension;Cerebral autoregulation;Laser Doppler;Transcranial Doppler;Ultrasonography
数据来源: OVID
摘要:
THE AIM OF the study was to correlate changes in transcranial Doppler blood flow velocity wave form in the basilar artery with cortical red blood cell flux measured with a laser Doppler flowmeter during hemorrhage-induced hypotension in anesthetized and ventilated New Zealand rabbits. Although systolic flow velocity and flux exhibited an autoregulatory threshold at 45 mm Hg, diastolic flow velocity started to fall when mean arterial blood pressure fell below 65 mm Hg. The difference between the mean arterial blood pressure at which diastolic blood flow velocity decreases and the pressure at which mean flux decreases is the difference between systolic and diastolic blood pressure. The increasing divergence between systolic and diastolic flow velocities was reflected in an increase in the amplitude of blood flow velocity pulsations and pulsatility indices. An increase in flux pulsatile wave form was noted as cerebral resistive vessels dilated with hypotension.
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