Recurrent venous thrombosis as the presenting manifestation of acute lymphocytic leukemia: Leukemic cell procoagulant activity is not responsible for the hypercoagulable state
作者:
Syed Bilgrami,
Bernard R. Greenberg,
Ralph E. Weinstein,
Gregory A. Hair,
Frederick R. Rickles,
期刊:
Medical and Pediatric Oncology
(WILEY Available online 1995)
卷期:
Volume 24,
issue 1
页码: 40-45
ISSN:0098-1532
年代: 1995
DOI:10.1002/mpo.2950240109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: venous thrombosis;procoagulant activity;hypercoagulable state
数据来源: WILEY
摘要:
AbstractThe association of cancer with clinical abnormalities of blood coagulation, including superficial thrombophlebitis, deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC) is well‐known, particularly in patients with solid tumors and acute promyelocytic leukemia (APL). Less commonly appreciated is the potential for the development of venous thromboembolic disease (TED) in patients with acute lymphocytic leukemia (ALL). Multiple mechanisms have been implicated for the activation of coagulation in these patients, with an emphasis on the contribution made by the procoagulant properties of the tumor cells themselves. We present two cases of patients with pre‐B cell ALL, both of whom developed recurrent TED as the presenting manifestation of their leukemia and/or heralding relapse. The blast cells from one of the patients were studied for the presence of procoagulant activity (PCA) and by Northern blot analysis for tissue factor (TF) messenger RNA (mRNA). Neither PCA nor TF mRNA could be identified in highly purified populations of the lymphoblast cells. We conclude that recurrent TED can be a manifestation of ALL and that mechanisms other than the release of tumor cell procoagulants should be sought to explain the pathogenesis of thrombosis in some patients. © 1995 Wiley‐Lis
点击下载:
PDF
(561KB)
返 回