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Advantages of a 6- to 7-Day Treatment with 40-mg Vaginal Suppositories of Terconazole against Vaginal Candidosis: Conclusions Drawn from a Phase II Multicentre Study in France

 

作者: M. Delecour,  

 

期刊: Gynäkologisch-geburtshilfliche Rundschau  (Karger Available online 1985)
卷期: Volume 25, issue 1  

页码: 42-51

 

ISSN:1018-8843

 

年代: 1985

 

DOI:10.1159/000269987

 

出版商: S. Karger AG

 

关键词: Antifungal agents;Terconazole;Vulvovaginal candidosis

 

数据来源: Karger

 

摘要:

The treatment duration in vaginal candidosis is still under discussion. Although a 3-day therapy with imidazoles is effective, many gynaecologists prescribe a 6-day therapy. Further, a recent double-blind study comparing 3 and 6 days’ treatments with econazole 150 mg demonstrated a lower relapse rate after 6 days’ therapy. It appeared to be necessary to develop a terconazole formulation adapted for this treatment duration. Our studies comparing various dosages demonstrated that 40 mg/day was adequate for a 6-day treatment. 102 patients with biologically proved vaginal candidosis were treated with this dosage. The mycological cure rate 1 week after treatment was 93%. Relapses occurred in only 12 % of the cured patients during the month following therapy. The product proved to be safe since only 2 patients experienced side-effects (burning/pruritus) not requiring discontinuation of the treatm

 

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