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Increased Systemic Activation of Neutrophils but Not Complement in Preeclampsia
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Increased Systemic Activation of Neutrophils but Not Complement in Preeclampsia
作者:
JAN MELLEMBAKKEN,
KOLBJØRN HØGÅSEN,
TOM MOLLNES,
C. HACK,
THOMAS ÅBYHOLM,
VIBEKE VIDEM,
期刊:
Obstetrics & Gynecology
(OVID Available online 2001)
卷期:
Volume 97,
issue 3
页码: 371-374
ISSN:0029-7844
年代: 2001
出版商: OVID
数据来源: OVID
摘要:
ObjectiveTo investigate whether neutrophils and systemic complement are activated in pregnancies complicated by preeclampsia more than in normal pregnancies.MethodsWe measured native complement components and activation products in plasma by enzyme immunoassays in 19 women with uncomplicated pregnancies, 15 with preeclampsia before cesarean deliveries, and 16 nonpregnant women. Neutrophil activation was measured by specific enzyme immunoassays for myeloperoxidase and lactoferrin.ResultsMyeloperoxidase was significantly higher in women with preeclampsia (197 μg/L, 95% confidence interval [CI] 94, 646) than in women with uncomplicated pregnancies (124 μg/L, 95% CI 70, 289;P= .009), whereas lactoferrin did not differ between groups. C4 was decreased in preeclamptic women (0.16 g/L, 95% CI 0.07, 0.48) compared with women with uncomplicated pregnancies (0.21, 95% CI 0.10, 0.30,P< .001). There were no differences for the other native complement components. There was a significant decrease in C1rs-C1 inhibitor, 13 AU/mL (95% CI 9, 34) versus 19 (95% CI 13, 38) (P≤ .001) in normal pregnant women compared with nonpregnant women. There also was an increase in C3, C4, C9 (data not shown), C4bp, 132% (95% CI 94%, 161%) versus 91% (95% CI 57%, 128%); C3bc (7.4 AU/mL, 95% CI 4.2, 10.7) versus 4.8 AU/mL (95% CI 3.2, 7.3) and C4bc (8.6 AU/mL, 95% CI 5.7, 14.0) versus 3.5 AU/mL (95% CI 2.2, 6.7) in normal pregnant women compared with nonpregnant women (P≤ .001).ConclusionNeutrophil activation in preeclampsia was shown by systemic increases in myeloperoxidase. Except for a decrease in C4, systemic complement activation could not be detected in preeclampsia.
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