Effect of Exchange Transfusions with Citrated Blood on Plasma Concentrations of Vitamin D Metabolites in Neonates
作者:
T MARKESTAD,
L AKSNES,
P H FINNE,
D AARSKOG,
期刊:
Pediatric Research
(OVID Available online 1984)
卷期:
Volume 18,
issue 5
页码: 429-431
ISSN:0031-3998
年代: 1984
出版商: OVID
关键词: CPD, citrate-phosphate-dextrose;DBP or ge globulin, vitamin D binding protein;1,25-(OH)2D, 1,25-dihydroxyvitamin D;24,25-(OH)2D, 24,25-dihydroxyvitamin D;25-OHD, 25-hydroxyvitamin D;PTH, parathyroid hormone
数据来源: OVID
摘要:
SummaryThe plasma concentrations of 25-hydroxyvitamin D (25- OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2D), and 24,25-dihydroxyvitamin D (24,25-(OH)2D) were determined pre- and postexchange, and in donors' blood in 10 blood exchange transfusions with citrated blood for neonatal hyperbilirubinemia. The postexchange concentrations of 25-OHD and 24,25- (OH)2D were intermediate between the levels before exchange and in donors' blood. Before therapy, the 1,25-(OH)2D concentrations were higher in the infants' than in donors' blood, and the pre-exchange levels were re-established during the procedure. The results suggest that postexchange concentrations of 25- OHD and 24,25-(OH)2D could be explained on the basis of redistribution of the metabolites between plasma and extravascular pools, whereas de novo synthesis was the most likely cause for the restoration of 1,25-(OH)2D levels.
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