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Simultaneous absence of the human IgG1, IgG2, IgG4 and IgA1 subclasses: Immunological and immunogenetical considerations

 

作者: Gérard Lefranc,   Hassen Chaabani,   Erna Van Loghem,   Marie‐Paule Lefranc,   Gerda De Lange,   Ahmed‐Noureddine Helal,  

 

期刊: European Journal of Immunology  （WILEY Available online 1983）
卷期: Volume 13, issue 3  

页码: 240-244

 

ISSN:0014-2980

 

年代: 1983

 

DOI:10.1002/eji.1830130312

 

出版商: WILEY‐VCH Verlag GmbH

 

数据来源: WILEY

 

摘要:

AbstractSimultaneous absence of the IgG1, IgG2, IgG4 and IgA1 immunoglobulins has been unambiguously demonstrated in a healthy 75‐year‐old woman by testing for allotypes, isoallotypes and for isotypes of these four subclasses. Only IgM, IgD, IgG3, IgA2 and IgE were present. The IgG3 levels were significantly increased. Family investigation showed inheritance of a haplotype Gm−;−;bA2m2. This person is homozygous for an extensive DNA deletion including the Cγ1, Cγ2, Cγ4 and

 

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