Modifications of factor VIII related antigen in hemophiliacs with acute hepatitis and sub‐clinical liver disease
作者:
Y. Sultan,
P. Maisonneuve,
J. Simeon,
L. Intrator,
期刊:
Scandinavian Journal of Haematology
(WILEY Available online 1977)
卷期:
Volume 19,
issue S30
页码: 16-26
ISSN:0036-553X
年代: 1977
DOI:10.1111/j.1600-0609.1977.tb01513.x
出版商: Blackwell Publishing Ltd
关键词: Hemophilia;Factor VIII concentrate;Post transfusion hepatitis;Factor VIII related antigen;von Willebrand activity;Ristocetin‐induced platelet aggregation
数据来源: WILEY
摘要:
Modifications of Factor VIII related antigen (F. VIII R. A.) were investigated in three hemophilic patients during the course of post transfusion hepatitis. F. VIII R. A. was found to be elevated and correlated with the increase of the S.G.P.T. During the acute phase of the disease the Factor VIII related protein was tested for its ristocetin cofactor activity, its electrophoretic mobility on crossed antigen‐antibody electrophoresis and its elution pattern on Sepharose 4B columns; all these properties proved to be abnormal.Liver function tests and F. VIII R. A. were measured in 36 multitransfused hemophiliacs. There was a significant increase of the F. VIII R. A. in the plasma of patients with abnormal liver function tests. Only a few of the multitransfused hemophiliacs had clinical symptoms of hepatitis, although 72 % had elevated transaminase level
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