Instead of the fixed pulse durations in conventional differential normal pulse voltammetry, a PC‐based instrument using adaptable pulse duration vectors for background current correction has been proposed and implemented. With this PC‐based instrument, a sequence of pulse duration vectors is determined in an initial blank solution voltammetry by assigning a decay percentage constant to the charging current. These vectors are then used in the subsequent test solution in order to obtain a pure oxidation current response in a resulting voltammogram with its corresponding features. Experimental results are presented to show the effectiveness and advantages of the PC‐based instrument for the measurements of dopamine in a phosphate buffered solution.