Selective inhibition of replicative and repair DNA synthesis in mouse colon following administration of 1,2‐dimethylhydrazine
作者:
ThomasM. Koval,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1984)
卷期:
Volume 13,
issue 1
页码: 117-124
ISSN:0098-4108
年代: 1984
DOI:10.1080/15287398409530485
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Early alterations in normal semiconservative and repair DNA synthesis were determined in gastrointestinal tissues of Ha/CR mice following administration of the colon carcinogen 1,2‐dimethylhydrazine (DMH). Following DMH injections of 60 and 200 mg/kg, normal DNA synthesis was rapidly inhibited in all tissues. The greatest depressions were observed in the descending colon, followed closely by the ascending colon. DNA repair was estimated by measuring unscheduled DNA synthesis. No repair was observable in the descending or ascending colon. The esophagus, forestomach, jejunum, and ileum demonstrated significant amounts of DNA repair, while the duodenum and gastric stomach displayed nominal or insignificant amounts of repair. Repair DNA synthesis was inhibited by simultaneous administration of caffeine and DMH.
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