Central antinociceptive effects of meloxicam on rat spinal cordin vitro
作者:
Jose-Antonio Lopez-Garcia,
Jennifer A. Laird,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 4
页码: 647-651
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Analgesia;Cyclooxygenase;Indomethacin;Inflammation;Meloxicam;NSAIDs;Pain;Spinal transmission
数据来源: OVID
摘要:
NON-STEROIDAL anti-inflammatory drugs inhibit constitutive (COX-1) and induced cyclooxygenase (COX-2), blocking prostaglandin production. We have compared the effects on nociceptive reflexes of meloxicam, which is COX-2 selective, with indomethacin, which is non-selective, using anin vitrospinal cord preparation. Cords were taken from naive rats, and from rats with carrageenan-induced hyperalgesia of one hindpaw. Reflex thresholds were lower in carrageenan preparations. Superfusion with meloxicam (10–100 μM) dose-dependently inhibited baseline reflexes and wind-up in normal and carrageenan preparations, whereas indomethacin (100–300 μM) had no effect. Thus meloxicam inhibits spinal reflexes, whereas indomethacin does not, despite its high affinity for both COX isoforms. We conclude that meloxicam has spinal antinociceptive actions which cannot be explained by the current concept of COX inhibition.
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