Paradoxical actions of the NO donor SIN‐I on single laryngeal motoneurons in the nucleus ambiguus
作者:
Yukio Yajima,
Yasumasa Hayashi,
Tetsu Hayakawa,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 4
页码: 765-769
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: Antidromic activation;Iontophoresis;Laryngeal motoneurons;NO donor SIN-I;Rats
数据来源: OVID
摘要:
In order to study the pharmacological action of the NO donor SIN-1 upon laryngeal motoneurons, we focally iontophoresed SIN-1 onto single motoneurons identified by antidromic stimulation of the recurrent nerve. SIN-1 produced opposing effects on motoneuron activities. Of 34 identified motoneurons, 38.2% showed a statistically significant decrease (decreasing group), while 29.4% showed an increase in their antidromic response to SIN-1 application (increasing group), respectively. The remaining neurons did not show any change (no change group). When the antidromic spike amplitude during the precontrol period was compared between the three groups, both the increasing and decreasing groups exhibited larger antidromic spikes than those measured in the no change group. The results are discussed in terms of dual pharmacological actions of NO.
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