Affinity of LDL to a human arterial proteoglycan among male survivors of myocardial infarction
作者:
T. LINDÉN,
G. BONDJERS,
G. CAMEJO,
R. BERGSTRAND,
L. WILHELMSEN,
O. WIKLUND,
期刊:
European Journal of Clinical Investigation
(WILEY Available online 1989)
卷期:
Volume 19,
issue 1
页码: 38-44
ISSN:0014-2972
年代: 1989
DOI:10.1111/j.1365-2362.1989.tb00304.x
出版商: Blackwell Publishing Ltd
关键词: Myocardial infarction;arterial proteoglycans;lipoproteins;LDL;atherosclerosis
数据来源: WILEY
摘要:
Abstract.In the present study, the hypothesis that the affinity of LDL to arterial proteoglycans might discriminate myocardial infarction patients from controls were tested. The patients were 52 men who had sustained a myocardial infarction at an age of 50 years or less and the controls, selected from a random population sample, were matched to the patients for age and sex. Serum cholesterol, triglycerides, LDL‐cholesterol, HDL‐cholesterol and apoB discriminated patients from controls. In addition, LDL reactivity with arterial proteoglycans was significantly higher in patients than in controls. In a multiple regression analysis, with patient or control as the dependent variable, apoB levels, LDL proteoglycan reactivity and serum triglycerides appeared as independent contributors to the regression. These observations indicate that LDL reactivity with arterial proteoglycans is a new, highly significant factor which discriminates between young myocardial infarction patients and contr
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