Effects of a traumatic neocortical lesion on cerebral metabolism and gene expression of rats
作者:
Dirk Hermann,
Günter Mies,
Konstantin-Alexander Hossmann,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1917-1921
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Bioluminescence imaging;Cerebral protein synthesis rate;Cortical spreading depression;Umbelliferone fluoroscopy
数据来源: OVID
摘要:
THE effects of a traumatic neocortical lesion, induced by transcranial cold injury, on brain metabolism and gene expression were examined. The surrounding of the lesions was characterized by increased glucose and lactate levels without major disturbances of protein synthesis or energy state. A transient pH decrease by 0.4 units was noticed 1 h post-injury, which shifted towards alkaline values by 3 h. The metabolic disturbances did not differ between injured animals with spontaneous spreading depressions (SD,n= 14) and those without SD (n= 7). In SD animals, c-fosmRNA was strongly elevated in the injury-remote cortex, buthsp72 mRNA was not enhanced. Thus, in contrast to focal ischemia, the metabolic dysfunction around traumatic cortical lesions is not aggravated by SD.
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