A Saturated Model for Analyzing Exchangeable Binary Data: Applications to Clinical and Developmental Toxicity Studies
作者:
Dale Bowman,
E.Olusegun George,
期刊:
Journal of the American Statistical Association
(Taylor Available online 1995)
卷期:
Volume 90,
issue 431
页码: 871-879
ISSN:0162-1459
年代: 1995
DOI:10.1080/01621459.1995.10476586
出版商: Taylor & Francis Group
关键词: Beta-binomial;Generalized estimating equations;Higher-order moments and correlations;Maximum likelihood estimates
数据来源: Taylor
摘要:
Correlated binary data occur very frequently in statistical practice. In many applications, it is reasonable to assume that data from the same cluster are exchangeable. Such data are commonly encountered in cluster sample surveys, teratological experiments, ophthalmologic and otolaryngologic studies, and other clinical trials. The standard methods of analyzing these data include the use of beta-binomial models and generalized estimating equations with third and fourth moments specified by “working matrices.” The focus of these procedures is an estimation of the mean and variance parameters. More information can be obtained when data are exchangeable. By expressing the joint distribution of a set of exchangeable binary random variables in terms of the probability of similar response within cluster, this article introduces a procedure for obtaining maximum likelihood estimates of population parameters such as the marginal means, moments, and correlations of orders two and higher. Applications are made to data sets from a clinical trial and a developmental toxicity study.
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