The Role ofMycobacterium tuberculosisin Experimental Allergic Encephalomyelitis
作者:
I.J. Namer,
J. Steibel,
P. Poulet,
Y. Mauss,
M. Mohr,
J. Chambron,
期刊:
European Neurology
(Karger Available online 1994)
卷期:
Volume 34,
issue 4
页码: 224-227
ISSN:0014-3022
年代: 1994
DOI:10.1159/000117043
出版商: S. Karger AG
关键词: Experimental allergic encephalomyelitis;Blood-brain barrier;Mycobacterium tuberculosis;Magnetic resonance imaging
数据来源: Karger
摘要:
Various detergents used in preparative membrane protein chemistry were added to a complete Freund’s adjuvant/water emulsion in order to increase the solubility and/or immunologic availability of the Mycobacterium tuberculosis membrane and to explain its role in blood-brain barrier (BBB) permeability. Magnetic resonance imaging was used for in vivo determination of the BBB breakdown and cerebral edema. The results showed that with 1% 10 tridecyl ether, which increases emulsion stability, abundant BBB breakdown and cerebral edema were observed, similar to those encountered in experimental allergic encephalomyelitis (EAE). We suggest that the immunologic response triggered off by M. tuberculosis largely contributes to the BBB permeability changes observed during EAE, probably by an action on the endothelial cells of the cerebral blood vessel
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