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The Interaction of Spironolactone and DigoxinA Review and Evaluation

 

作者: Russel Thomas,   Ray Maddox,  

 

期刊: Therapeutic Drug Monitoring  （OVID Available online 1981）
卷期: Volume 3, issue 2  

页码: 117-120

 

ISSN:0163-4356

 

年代: 1981

 

出版商: OVID

 

关键词: Digoxin;Spironolactone;Radioimmunoassay interference;Pharmacokinetics

 

数据来源: OVID

 

摘要:

A review of the literature describing the interaction of digoxin and spironolactone is presented. Two mechanisms of possible interaction are discussed. Spironolactone and its metabolites may interfere with digoxin radioimmunoassay or alter the pharmacokinetics of digoxin. The occurrence of either or both of these processes may make interpretation of serum digoxin levels difficult.

 

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