Cocaine abusers (N= 42) from an inpatient drug rehabilitation program were interviewed regarding combined use of cocaine with alcohol or cigarettes. Concurrent use of alcohol and cocaine was reported by 37 patients and concurrent use of cigarettes and cocaine by 41 patients. All but two concurrent users reported simultaneous use of alcohol or cigarettes with cocaine. Increased cocaine effect was perceived by 43% of simultaneous alcohol users compared with 15% of simultaneous cigarette users. Patients experienced decreased craving for cocaine and alcohol during treatment, but craving for cigarettes remained essentially unchanged.