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Use of Inverse Multiple Linear Regression (ILS) for the Analytical Control of Pharmaceutical Preparations. UV-Visible Spectrophotometric Quantitation of an Active Principal in the Presence of Absorbing Excipients

 

作者: M. Blanco,   J. Coello,   H. Iturriaga,   S. Maspoch,   S. Alaoui-Ismaili,  

 

期刊: Analytical Letters  （Taylor Available online 1999）
卷期: Volume 32, issue 6  

页码: 1169-1181

 

ISSN:0003-2719

 

年代: 1999

 

DOI:10.1080/00032719908542886

 

出版商: Taylor & Francis Group

 

关键词: Inverse Multiple Regression;Sodium picosulphate;UV-Visible analysis

 

数据来源: Taylor

 

摘要:

The simplicity and robustness of inverse multiple linear regression (ILS) as a method for the analytical control of pharmaceutical preparations by UV–vis spectrophotometry is demonstrated. This calibration technique establishes a linear relation between the analyte concentration as dependent variable and absorbance values measured at a small number of wavelengths as independent variables. In this work, ILS was used to quantify the active principal in a pharmaceutical preparation commercially available as aqueous solution.

 

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