A 31-year-old female patient with both acquired immunodeficiency syndrome and a solid silicone buttock implant presented with fever. Using ultrasound-guided aspiration of the periprosthetic space, a diagnosis ofMycobacterium aviumcomplex infection involving the implant was made. The implant was surgically removed and the patient had a resolution of her fevers while treated with ethambutol, rifabutin, ciprofloxacin, and clarithromycin.