Many challenges related to the development and diagnosis of cancer are faced by adolescents with the disease. Adolescence is a developmental period for behaviors that risk health. The article describes behaviors that promote and risk health among adolescents who have been diagnosed with cancer. A paucity of studies exists on health-promoting and-risking behaviors among adolescents with cancer. Further studies are needed to explore and describe these adolescents' health-promoting and-risking behaviors. Health care professionals must comprehensively address these adolescents' health care needs related to the diagnosis of cancer as well as the developmental challenges of adolescence.