Nicarbazin contamination in feeds as a cause of residues in eggs
作者:
Andrew Cannavan,
Glyn Ball,
D. Glenn Kennedy,
期刊:
Food Additives & Contaminants
(Taylor Available online 2000)
卷期:
Volume 17,
issue 10
页码: 829-836
ISSN:0265-203X
年代: 2000
DOI:10.1080/026520300420394
出版商: Taylor & Francis Group
关键词: Nicarbazin Residues Contamination Eggs
数据来源: Taylor
摘要:
A survey was carried out to investigate the prevalence of nicarbazin residues in eggs in Northern Ireland. Nicarbazin, in the form of 4,4′-dinitrocarbanilide (DNC), was detected in 39 of the 190 eggs analysed. An experiment was designed to establish the relationship between nicarbazin-contaminated feed and nicarbazin residues in eggs. The concentrations of both the DNC and 4,6-dimethyl-2-hydroxypyrimidine (DHP) components of the drug in eggs were proportional to feed levels. The maximum feed nicarbazin concentration of 12.1mg/kg (8.6 mg/kg DNC and 3.5mg/kg DHP) gave rise to mean maximum whole egg concentrations of 631 μg/kg DNC and 51.8 μg/kg DHP. After withdrawal of the experimental diet, DNC was undetectable in eggs after 12 days and DHP after 3 days. Feed contaminated with nicarbazin at concentrations greater than about 2mg/kg gave rise to egg DNC residues at concentrations greater than the Differential Action L imit (DAL) set by the UK (100 μg/kg). DNC was contained almost entirely in the yolk of the egg, whereas DHP was distributed between albumen and yolk in a ratio of approximately 3:1.
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