Potassium-Sparing Diuretics
作者:
Jean-Daniel Horisberger,
Gerhard Giebisch,
期刊:
Kidney and Blood Pressure Research
(Karger Available online 1987)
卷期:
Volume 10,
issue 3-4
页码: 198-220
ISSN:1420-4096
年代: 1987
DOI:10.1159/000173130
出版商: S. Karger AG
关键词: Na-K pump;Na+conductance;K+secretion;Amiloride;Na+reabsorption;Triamterene;Spirolactones;Aldosterone;Distal tubule;Collecting duct
数据来源: Karger
摘要:
Amiloride, triamterene, and the spirolactones are potassium-sparing diuretics which act on the distal parts of the nephron, from the late distal tubule to the collecting duct. In these segments, active sodium reabsorption occurs through the following mechanism: sodium ions enter the cell through specific channels present in the luminal membrane and are extruded out of the cell into the peritubular medium by a sodium-potassium exchange pump, the Na-K-ATPase. Amiloride in micromolar concentrations reduces the sodium transport by blocking the luminal membrane sodium channel. Triamterene has a similar effect, although with a lower affinity; the available studies do not allow to determine if an inhibitory effect of triamterene on the Na-K-ATPase plays an additional role in its diuretic action. The spirolactones are competitive inhibitors of aldosterone, the mineralocorticoid hormone which
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