首页   按字顺浏览 期刊浏览 卷期浏览 Specific break points in chromosomally abnormal human fibroblast subpopulations
Specific break points in chromosomally abnormal human fibroblast subpopulations

 

作者: P.A. Benn,  

 

期刊: Cytogenetic and Genome Research  (Karger Available online 1977)
卷期: Volume 19, issue 2-3  

页码: 118-135

 

ISSN:1424-8581

 

年代: 1977

 

DOI:10.1159/000130803

 

出版商: S. Karger AG

 

数据来源: Karger

 

摘要:

Common chromosome break points were found in a banding study of 25 chromosomally abnormal fibroblast clones derived from normal individuals and patients exposed to environmental carcinogens. Of 81 break points, 38 % appeared to be in terminal bands. This specificity did not appear to be the consequence of the biased recognition of exchanges. In addition, specificities for break points at exact interstitial loci were detected. The presence of clones in cultures grown in a wide variety of conditions, the finding of two identical clones in two independent lines from the same biopsy, and the absence of any obvious continuing instability in lines support the view that chromosomally abnormal fibroblasts occur in vivo.

 

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