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Endurance training and human α2-adrenergic receptors on platelets

 

作者: WARREN LOCKETTE,   ROBERT MCCURDY,   STUART SMITH,   OSCAR CARRETERO,  

 

期刊: Medicine and Science in Sports and Exercise  (OVID Available online 1987)
卷期: Volume 19, issue 1  

页码: 7-10

 

ISSN:0195-9131

 

年代: 1987

 

出版商: OVID

 

数据来源: OVID

 

摘要:

LOCKETTE, W., R. MCCURDY, S. SMITH, and O. CARRETERO. Endurance training and human α2-adrenergic receptors on platelets.Med. Sci. Sports Exerc., Vol. 19, No. 1, pp. 7–10, 1987. Trained endurance athletes have a smaller rise in blood pressure, heart rate, and catecholamine response to stress when compared to an untrained, control population. Since pre-synaptic α2-adrenergic receptors modulate the control of epinephrine release from nerve terminals, and since platelets are used as models of monoaminergic neurons, we investigated changes in the number and affinity binding of α2-adrenergic receptors on platelets from endurance athletes and a sedentary population using the radiolabeled ligand yohimbine. We found, compared to a control, sedentary population, trained athletes had a 45% increase in the number of platelet α2-adrenergic receptors (338 ± 39 receptors/platelet vs 233 ± 25 receptors/platelet,P< 0.05) with no change in the dissociation constant (2.53 nM ± 0.2 vs 2.24 nM ± 0.2, NS) or the ED50concentration for the competitive displacement of 2.5 nM yohimbine by epinephrine (2.8 x 10-6M vs 3.34 x 10-6M, NS). The increase in α2-adrenergic receptors found in athletes may explain their decreased catecholamine response and concomitant physiologic responses to exertion.

 

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